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History of Antibody Labeling Agents

From Mary Bellis,
Your Guide to Inventors.
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Burckhalter and Seiwald invented the first patented antibody labeling agent.

Joseph Burckhalter and Robert Seiwald invented the first practical and patented antibody labeling agent. What Burckhalter and Seiwald achieved was a practical and economic method of making synthesized fluorescein isothiocyanate or FITC. An antibody labeling agent, FITC is a dye used for diagnosing infectious disease that is now used widely for numerous infectious diseases, including AIDS, syphilis, leukemia, and lymphoma.

What Is An Antibody? What Is An Antigen?

An antibody is a protein used by the immune system to identify and neutralize bacteria, viruses, and foreign objects. Bacteria and viruses each produce a unique molecule called an antigen which the antibody uses to recognize its target.

First Patented Antibody Labeling Agent

Patent Number 2,937,186 for "Isothiocyanate Compounds and Means of Producing the Same Isothiocyanate Compounds" was issued to Joseph Burckhalter and Robert Seiwald on May 17, 1960.

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